Basic Information
| LncRNA/CircRNA Name | circCCDC66 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | RNA interference knockdown, Molecular cloning, RT-PCR |
| Sample | colorectal cancer and the non-tumorous tissues , colon cancer cell lines, HT-29 and HCT116 |
| Expression Pattern | up-regulated |
| Function Description | CircCCDC66 expression was elevated in polyps and colon cancer and was associated with poor prognosis. Gain-of-function and loss-of-function studies in CRC cell-lines demonstrated that circCCDC66 controlled multiple pathological processes, including cell proliferation, migration, invasion, and anchorage-independent growth. In-depth characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft and orthotopic mouse models, respectively |
| Pubmed ID | 28249903 |
| Year | 2017 |
| Title | Non-coding effects of circular RNA CCDC66 promote colon cancer growth and metastasis |
External Links
| Links for circCCDC66 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |