Basic Information
| LncRNA/CircRNA Name | circCDR1as |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-PCR, Cell viability assay, Cell cycle assay, Annexin V/propidium iodide apoptosis assay, Colony-formation assay, Cell invasion assay, Western blot |
| Sample | human primary CRC tissues and normal mucosa tissues, The human CRC cell lines, HCT-116 and DLD-1, and human normal colonic epithelium cell lines, NCM460 and CCD841CoN |
| Expression Pattern | up-regulated |
| Function Description | CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression. Intriguingly, ectopic expression of miR-7 in CRC cells consistently inhibited proliferation and invasion, and the miR-7 inhibitor was able to rescue the function of CDR1as knockdown. Mechanistic studies demonstrated that CDR1as silencing suppressed EGFR and IGF-1R expression, which could be partially blocked by the miR-7 inhibitor. Finally, positive correlations between CDR1as expression and EGFR and IGF-1R expression were observed in CRC samples. |
| Pubmed ID | 28435295 |
| Year | 2017 |
| Title | Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7 |
External Links
| Links for circCDR1as | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |