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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular cancer
ICD-0-3	NA
Methods	reverse transcription, PCR, Cloning and sequencing of qRT-PCR products, blood
Sample	HCC tissues and adjacent non-tumorous -tissues, HCC cell lines, HepG2 and SMMC-7721, and human normal hepatic cell line L02, MHCC97L, MHCC97H, and HCCLM3
Expression Pattern	down-regulated
Function Description	Hsa_circ_0003570 was not only first found down-regulated in HCC cell lines (P<.001) but also in HCC tissues (P<.001). Moreover, hsa_circ_0003570 was gradually decreased from chronic hepatitis (CH), to liver cirrhosis (LC) and to HCC tissues (P<.01). Its expression levels were significantly correlated with tumor diameter (P=.035), differentiation (P=.013), microvascular invasion (P=.045), Barcelona Clinic Liver Cancer stages (P=.011), tumor-node-metastasis stages (P=.016), and serum alpha-fetoprotein levels (P=.031). The ROC curve demonstrated that hsa_circ_0003570 had poor performance for differentiating HCC from LC and CH, but had relatively good performance for differentiating LC from CH
Pubmed ID	28493512
Year	2017
Title	Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance

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