Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP |
| Sample | glioma tissues, cell lines (U87,LN229,HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 expression was significantly increased, while miR-181b decreased,in glioma tissues. Interestingly, miR-181b expression was negatively correlated with the CCAT1 level in glioma samples. Knockdown of CCAT1 notably suppressed proliferation, migration and the epithelial-mesenchymal transition (EMT) process, and promoted the apoptosis of U87 and LN229 glioma cells, which could be enhanced by transfection with miR-181b mimic while it was abolished by anti-miR-181b.CCAT1 may act as a competing endogenous RNA (ceRNA) for miR-181b, regulating the de-repression of FGFR3 and PDGFRa. |
| Pubmed ID | 28475287 |
| Year | 2017 |
| Title | lncRNA CCAT1 Promotes Glioma Tumorigenesis by Sponging miR-181b. |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |