Basic Information
| LncRNA/CircRNA Name | circ_0013958 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | RT-PCR, Cell proliferation assay, Cell migration and invasion assays, Flow cytometry analysis, Western blotting analysis, Luciferase reporter assay, RNA-FISH |
| Sample | primary LAC and noncancer tissues, A549 and H1299 cells, blood |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_0013958 was further confirmed to be up-regulated in all of the LAC tissues, cells and plasma. In addition, hsa_ circ_0013958 levels were associated with TNM stage (P = 0.009) and lymphatic metastasis (P = 0.006). The area under the receiver operating characteristic curve was 0.815 (95% confidence interval = 0.727-0.903; P < 0.001). In addition, to further illustrate the bioactivities of hsa_ circ_0013958 in LAC, siRNA-mediated inhibition of hsa_circ_0013958 was performed in vitro. The results showed that hsa_circ_0013958 promoted cell proliferation and invasion and inhibited cell apoptosis in LAC. Moreover, hsa_circ_0013958 was identified as a sponge of miR-134, and thus it upregulated oncogenic cyclin D1, which plays a pivotal role in the development of non-small cell lung cancer |
| Pubmed ID | 28685964 |
| Year | 2017 |
| Title | hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma |
External Links
| Links for circ_0013958 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |