Basic Information
| LncRNA/CircRNA Name | circ_100338 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, In vitro invasion assay, Luciferase activity assays |
| Sample | HCC tissue and matched para-carcinoma tissue, HCC cell lines Hep3B, BEL7402, MHCC97H and HCCLM6 |
| Expression Pattern | up-regulated |
| Function Description | High expression of circRNA_100338, one of the upregulated circRNAs in HCC, is closely correlated with a low cumulative survival rate and metastatic progression in HCC patients with hepatitis B. Furthermore, our in silico and experimental analyses identified miR-141-3p as a direct target of circRNA_100338. Thus, circRNA_100338 functions as an endogenous sponge for miR-141-3p in HCC. In addition, we identified the crucial antagonistic roles of circRNA_100338 and miR-141-3p in the regulation of invasive potential in liver cancer cells. |
| Pubmed ID | 28710406 |
| Year | 2017 |
| Title | Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma |
External Links
| Links for circ_100338 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |