Basic Information
| LncRNA/CircRNA Name | circABCB10 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, siRNA transfection, Luciferase reporter assay, CCK-8 proliferation assay, Colony formation, Flow cytometry |
| Sample | cancer and adjacent noncancerous tissue, Human breast cancer cell lines (MCF-7, MDAMB-231, MDA-MB-468, MDA-MB-453) and normal human breast epithelial cells (MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | circ-ABCB10, was significantly up-regulated in breast cancer tissue. And results were replicated in a larger sample size. In vitro, lossof-function experiments showed circ-ABCB10 knockdown suppressed the proliferation and increased apoptosis of breast cancer cells. Bioinformatics prediction program predicted the complementary sequence within circ-ABCB10 and miR-1271, which was validated by luciferase reporter assay. Finally, miR-1271 rescued the function of circ-ABCB10 on breast cancer cells, confirming the sponge effect of circ-ABCB10 on miR-1271 |
| Pubmed ID | 28744405 |
| Year | 2017 |
| Title | Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271 |
External Links
| Links for circABCB10 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |