Basic Information
| LncRNA/CircRNA Name | circSMARCA5 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA interference and transient transfection, PCR, Cell proliferation assay, Cell cycle and annexin V-FITC apoptosis assay |
| Sample | LNCaP cells, 22RV1, DU145, PC-3 and WPMY-1, prostate cancer, match normal prostate tissues |
| Expression Pattern | up-regulated |
| Function Description | circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer. |
| Pubmed ID | 28765045 |
| Year | 2017 |
| Title | Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer |
External Links
| Links for circSMARCA5 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |