Basic Information
| LncRNA/CircRNA Name | circHIPK3 |
| Synonyms | circBCRC_2 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | PCR, Northern blots, stable transfection, Oligonucleotide transfection, Pull-down assay, Tube formation assay, Western blots, Wound healing assay, Transwell migration and matrigel invasion assays, Immunohistochemistry |
| Sample | bladder cancer tissues and paired adjacent normal bladder tissues, The human metastatic bladder cancer cell line T24T, Human invasive bladder cancer cell line UMUC3(CRL-1749), human immortalized uroepithelium cell line SV-HUC-1 (CRL-9520), and endothelial cell line HUVEC (CRL-1730) |
| Expression Pattern | down-regulated |
| Function Description | circHIPK3, also named bladder cancer-related circular RNA-2 (BCRC-2), is significantly down-regulated in bladder cancer tissues and cell lines, and negatively correlates with bladder cancer grade, invasion as well as lymph node metastasis, respectively. Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppresses bladder cancer growth and metastasis in vivo. Mechanistic studies reveal that circHIPK3 contains two critical binding sites for the microRNA miR558 and can abundantly sponge miR-558 to suppress the expression of heparanase (HPSE). |
| Pubmed ID | 28794202 |
| Year | 2017 |
| Title | CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells |
External Links
| Links for circHIPK3 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |