Basic Information
| LncRNA/CircRNA Name | circ 0006528 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western blotting |
| Sample | MCF-7 and MDA-MB-231 human breast cancer cell lines, ADM-resistant cell lines (MCF-7/ADM and MDA-MB-231/ADM), ADM-resistant tissues, ADM-sensitive tissues |
| Expression Pattern | up-regulated |
| Function Description | We detected 3093 circRNAs and identified 18 circRNAs that are differentially expressed between MCF-7/ADM and MCF-7 cells; after validating by quantitative real-time reverse transcription PCR, we predicted the possible miRNAs and potential target genes of the seven upregulated circRNAs using TargetScan and miRanda. The bioinformatics analysis revealed several target genes related to cancer-related signaling pathways. Additionally, we discovered a regulatory role of the circ 0006528-miR-7-5p-Raf1 axis in ADMresistant breast cancer.A total of seven upregulated (hsa circ 0002113, hsa circ 0002874, hsa circ 0006528, hsa circ 0001667, hsa circ 0085495, hsa circ 0086241 and hsa circ 0092276) and one downregulated (hsa circ 0003838) circRNAs were verified (Figure 2B). |
| Pubmed ID | 28803498 |
| Year | 2017 |
| Title | Screening circular RNA related to chemotherapeutic resistance in breast cancer |
External Links
| Links for circ 0006528 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |