Basic Information
| LncRNA/CircRNA Name | circCDR1as |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Cell cycle progression assay, Cell proliferation assay, Wound healing assay, Cell invasion assay, Cell adhesion assay, Western blot analysis, RNA-FISH analysis |
| Sample | hepatocellular carcinoma cell lines HepG2 and Huh7, an normal human liver epithelial cell line THLE-3, as well as human breast cancer cell line MCF-7, human cervical cancer cell line HeLa and human embryonic kidney cell line 293T, HCC samples and the matched non-tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | we identified 330 differentially expressed proteins (DEPs) upon enhanced CDR1as expression in HepG2 cells, indicating that they could be proteins regulated by CDR1as. Bioinformatic analysis revealed that many DEPs were involved in cell proliferation and the cell cycle. Further functional studies of epidermal growth factor receptor (EGFR) found that CDR1as exerts its effects on cell proliferation at least in part through the regulation of EGFR expression. We further confirmed that CDR1as could inhibit the expression of microRNA-7 (miR-7). EGFR is a validated target of miR-7; therefore, CDR1as may exert its function by regulating EGFR expression via targeting miR-7 in HCC cells. |
| Pubmed ID | 28892615 |
| Year | 2017 |
| Title | Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells |
External Links
| Links for circCDR1as | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |