Basic Information
| LncRNA/CircRNA Name | circUBAP2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Cell proliferation analysis, Tumor growth analysis in vivo, Detection of apoptosis, Western blot |
| Sample | Human osteosarcoma tumor tissues and matched adjacent normal tissues, Human osteoblastic cell line hFOB 1.19, osteosarcoma cell lines MG63 and U2OS |
| Expression Pattern | up-regulated |
| Function Description | circRNA UBAP2 (circUBAP2) expression is significantly increased in human osteosarcoma tissues as compared to those in matched controls. Increased circUBAP2 expression was significantly correlated with human osteosarcoma progression and prognosis. Furthermore, increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both in vitro and in vivo. Mechanistically, circUBAP2 was found to inhibit the expression of microRNA-143 (miR-143), thus enhancing the expression and function of anti-apoptotic Bcl-2, which is a direct target of miR-143. |
| Pubmed ID | 28977896 |
| Year | 2017 |
| Title | Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression |
External Links
| Links for circUBAP2 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |