Basic Information
| LncRNA/CircRNA Name | circ_0001785 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | PCR, CircRNA Microarray assay |
| Sample | blood, biopsy and surgical mammary tissue specimens. |
| Expression Pattern | down-regulated |
| Function Description | CircRNAs microarray assay showed that 41 circRNAs were aberrantly expressed with 2 fold change, including 19 up-regulated and 22 down-regulated circRNAs. Among these circRNAs, 3 candidate circRNAs were validated to be significantly dysregulated using RT-PCR, including hsa_circ_0001785, hsa_circ_0108942 and hsa_circ_0068033. In lager study cohort (n=20), ROC curve showed that hsa_circ_0001785 had better diagnostic value (AUC=0.771) than others. Moreover, in further extensive study cohort (n=57), we found that hsa_circ_0001785 plasma had better diagnostic accuracy (AUC=0.784) than CEA (AUC=0.562) and CA15-3 (AUC=0.629). Besides, hsa_circ_0001785 plasma level was closely related to histological grade (P=0.013), TNM stage (P=0.008) and distant metastasis (P=0.016). Furthermore, hsa_circ_0001785 plasma level in postoperative patients (0.283?0.043) was significantly lower than that of preoperative patients (0.109?0.037, P<0.01 |
| Pubmed ID | 29045858 |
| Year | 2017 |
| Title | Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection |
External Links
| Links for circ_0001785 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |