Basic Information
| LncRNA/CircRNA Name | circ_0061276 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | reverse transcription, qPCR, Cloning and sequencing of RT-ddPCR products |
| Sample | Gastric cancer tissues and fasting plasma samples, The gastric cancer cell lines BGC-823, MGC-803, and SGC7901 and normal human gastric epithelial cell line GES-1 |
| Expression Pattern | down-regulated |
| Function Description | Their levels were significantly associated with distal metastasis. The area under receiver operating characteristic curve in combinative use was 0.966 with 95.5% sensitivity and 95.7% specificity. Patients with low plasma hsa_circ_0001017 or hsa_circ_0061276 had a much shorter overall survival than those with high levels. Patients whose plasma hsa_circ_0001017 or hsa_circ_0061276 levels recovered to normal after operation had a longer disease-free survival. Finally, the in vitro model indicated gastric cancer cells secreting circRNAs into plasma. |
| Pubmed ID | 29098316 |
| Year | 2017 |
| Title | Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection |
External Links
| Links for circ_0061276 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |