Basic Information
| LncRNA/CircRNA Name | circ_0085154 |
| Synonyms | circARSP91 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | PCR, luciferase assays, IHC, ChIP assay, MTT assay and colony formation assay, Invasion assay |
| Sample | The MHCC-97h, LM3 and LO2 cells, The SK-Hep1, HepG2, Huh7 and SD cells, primary tumors and adjacent non-tumor liver tissues |
| Expression Pattern | down-regulated |
| Function Description | AR could suppress circRNA expression by upregulating ADAR1 p110. Such effect is because AR served as a transcriptional activator of ADAR1 promoter. More significantly, data collected from our center strongly suggest that ADAR1 expression can effectively predict HCC patients??prognosis and an abnormal overexpression of ADAR1 is positively correlated with AR in HCC. In addition, we found CircARSP91 (hsa_circ_0085154), one of the circRNAs downregulated by AR in an ADAR1-dependent manner, could inhibit HCC tumor growth both in vitro and in vivo. |
| Pubmed ID | 29144509 |
| Year | 2017 |
| Title | Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma |
External Links
| Links for circ_0085154 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |