Basic Information
| LncRNA/CircRNA Name | circ_000984 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | PCR, luciferase reporter assay, Cell proliferation assay, colony formation assay and cell cycle assay |
| Sample | CRC tumors and matched adjacent normal tissues, Human CRC cell lines (SW480, SW620 and HT29 cells) and normal colon-derived cell (CCD-18Co) and human intestinal epithelial cells (InEpC) |
| Expression Pattern | up-regulated |
| Function Description | we found circular RNA hsa_circ_000984 encoded by the CDK6 gene was remarkably upregulated in the tissues of colorectal cancer (CRC) patients and in the CRC cell lines. Moreover, high expression level of hsa_circ_000984 was significantly associated with advanced colorectal cancer. Further analysis revealed that hsa_circ_000984 knockdown could inhibit cell proliferation, migration, invasion in vitro and tumor formation in vivo in CRC cell lines. Mechanically, we found that hsa_circ_000984 may act as a competing endogenous RNA (ceRNA) by competitively binding miR106b and effectively upregulate the expression of CDK6, thereby inducing a series of malignant phenotypes of tumor cells. |
| Pubmed ID | 29207676 |
| Year | 2017 |
| Title | Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b |
External Links
| Links for circ_000984 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |