Basic Information
LncRNA/CircRNA Name | circVRK1 |
Synonyms | |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | breast cancer |
ICD-0-3 | C50 |
Methods | qPCR, Western blot |
Sample | The human breast cancer cell line MCF-7 and MDA-MB-231 |
Expression Pattern | down-regulated |
Function Description | 27 circRNAs were found to be aberrantly expressed. Of these, 19 circRNAs were downregulated and 8 were upregulated and some of these circRNAs were validated by Q-PCR. Furthermore, we constructed the circRNA/miRNA network by bioinformatics approaches and hypothesized that circRNAs might be involved in stemness of BCSCs via serving as miRNA sponges. Importantly, we found that circular RNA VRK1 (circVRK1) could suppress BCSC?? expansion and self-renewal capacity. Collectively, the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. |
Pubmed ID | 29221160 |
Year | 2017 |
Title | Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells |
External Links
Links for circVRK1 | GenBank HGNC NONCODE |
Links for breast cancer | OMIM COSMIC |