Basic Information
| LncRNA/CircRNA Name | circ_404833 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | tumor tissues and lung cancer cell lines (A549 & H1299), normal tissues or human pulmonary bronchial epidermal cell lines (BEAS-2B, B2B) |
| Expression Pattern | up-regulated |
| Function Description | To confirm the microarray data, we randomly selected five differentially expressed circRNAs, including two up-regulated (hsa_circRNA_406483 and hsa_circRNA_404833) and three down-regulated (hsa_circRNA_001640, hsa_circRNA_006411 and hsa_ circRNA_401977) circRNAs the expression patterns of selected circRNAs were consistent with the microarray data in the tumor samples (Fig. 3A), but the expression of hsa_circRNA_406483 and hsa_circRNA_001640 in the lung cancer cell lines did not match well with the microarray data, the PCR products were cloned into a pEasy-3T vector for further sequence identification, and the results showed that those PCR products were exactly the indicated circRNAs with a back spliced junction, and the cyclic patterns of circRNAs were described according to the associated gene exons. |
| Pubmed ID | 29241190 |
| Year | 2017 |
| Title | CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients |
External Links
| Links for circ_404833 | GenBank HGNC NONCODE |
| Links for Lung Adenocarcinoma | OMIM COSMIC |