Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Cell proliferation assay etc. |
| Sample | pancreatic cancer tissues, cell lines (PANC-1 and Aspc-1) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 was highly expressed in PC tissues compared to the adjacent tissues and was also overexpressed in PANC-1 and Aspc-1 cells. The silencing of CCAT1 significantly inhibited cell proliferation and migration, arrested cell cycle at G0/G1 stage, and decreased cyclin D1 expression. An increased expression of c-Myc was observed in the PC tissues compared to the adjacent tissues. |
| Pubmed ID | 28078015 |
| Year | 2017 |
| Title | Long non-coding RNA CCAT1 that can be activated by c-Myc promotes pancreatic cancer cell proliferation and migration. |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |