Basic Information
| LncRNA/CircRNA Name | circHIPK3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR |
| Sample | BC cell lines RT4, HT1376, T24, FL3, immortalized human bladder epithelium HCV29, publicly available tissue |
| Expression Pattern | down-regulated |
| Function Description | Analysis of progression-free survival revealed 13 circRNAs, among them circHIPK3 and circCDYL, where expression correlated with progression independently of the linear transcript and the host gene. In summary, our results demonstrate that abundant circRNAs possess multiple biological features, distinguishing them from low-expressed circRNAs and non-circularized exons, and suggest that circRNAs might serve as a new class of prognostic biomarkers in NMIBC.Kaplan-Meier survival analysis revealed a significantly lower risk of progression for patients with high circHIPK3 and circCDYL expression levels compared to patients with low levels |
| Pubmed ID | 29263845 |
| Year | 2017 |
| Title | Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer |
External Links
| Links for circHIPK3 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |