Basic Information
| LncRNA/CircRNA Name | circDOCK1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | Microarray, qPCR, Western blot |
| Sample | The human OSCC cell lines CAL-27, SCC-9 and SCC-25, Human normal oral epithelial keratinocytes (HOK), oral carcinoma tissues and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | The knockdown of the expression of circDOCK1 led to the increase of apoptosis. Utilizing multiple bioinformatics methods, we predicted the interactions among circRNAs, miRNAs and genes, and built the circDOCK1/miR-196a-5p/BIRC3 axis. Both the silencing of circDOCK1 with small interfering RNA and the upregulation of the expression of miR-196a-5p with mimics led OSCC cells to increase apoptosis and decrease BIRC3 formation. We further confirmed this outcome by comparing the expression of circDOCK1, miR-196a-5p and BIRC3 in oral squamous carcinoma tissue with those in para-carcinoma tissue, and examining the expression profile of circRNAs in oral squamous carcinoma tissue and para-carcinoma tissue with microarray |
| Pubmed ID | 29286141 |
| Year | 2017 |
| Title | CircDOCK1 suppresses cell apoptosis via inhibition of miR-196a-5p by targeting BIRC3 in OSCC |
External Links
| Links for circDOCK1 | GenBank HGNC NONCODE |
| Links for Oral squamous cell carcinoma | OMIM COSMIC |