Basic Information
| LncRNA/CircRNA Name | circ_0075930 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, western blot, other |
| Sample | lung adenocarcinoma tissues and cell lines (A549, H1299, H460, and Calu1) |
| Expression Pattern | up-regulated |
| Function Description | The elevated hsa_circ_0075930 expression was correlated with tumor size (P = 0.001) and Lymph node metastasis (P = 0.038). Functional experiments showed knockdown of hsa_circ_0075930 followed by RNA silencing restrained cell proliferation and induced cell cycle arrest of NSCLC cells. In addition, hsa_circ_0075930 suppression impaired migration and invasion potential by reversing epithelial-to-mesenchymal transition (EMT). |
| Pubmed ID | 29689350 |
| Year | 2018 |
| Title | Hsa_circ_0079530 Promotes Cell Proliferation and Invasion in Non-Small Cell Lung Cancer |
External Links
| Links for circ_0075930 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |