Basic Information
| LncRNA/CircRNA Name | circ_0071589 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, western blot, RIP, other |
| Sample | colon cancer tissues and cell line (HCT116) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that hsa_circ_0071589 expression was significantly higher in CRC tissues than in normal tissues. Blockage of hsa_circ_0071589 in CRC cells inhibited tumor growth, invasion and migration. Hsa_circ_0071589 was able to promote the expression of EZH2 by acting as a sponge of miR-600. In addition, miR-600 expression was negatively correlated to hsa_circ_0071589 expression in CRC tissues. These results demonstrated that the hsa_circ_0071589/miR-600/EZH2 axis may play critical regulatory roles in the pathogenesis of CRC and may serve as a novel therapy target in CRC. |
| Pubmed ID | 29710537 |
| Year | 2018 |
| Title | Hsa_circ_0071589 Promotes Carcinogenesis via the miR-600/EZH2 Axis in Colorectal Cancer |
External Links
| Links for circ_0071589 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |