Basic Information
| LncRNA/CircRNA Name | circ_0016788 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, other |
| Sample | HCC tissues and cell lines (HepG2, Hep3B, Huh7, HCCLM3, MHCC97L,) |
| Expression Pattern | up-regulated |
| Function Description | Loss-of-functional experiments in vivo and vitro revealed that hsa_circ_0016788 silencing inhibited the proliferation, invasion and promoted the apoptosis in vitro, and inhibited the tumor growth in vivo. Bioinformatics tools and luciferase reporter assay validated that miR-486 targeted hsa_circ_0016788 and CDK4 accompanying with negatively correlated expression, suggesting the hsa_circ_0016788/miR-486/CDK4 pathway. Receiver operating characteristic (ROC) curve showed that hsa_circ_0016788 had high diagnostic value (AUC = 0.851). |
| Pubmed ID | 29923236 |
| Year | 2018 |
| Title | Circular RNA hsa_circ_0016788 Regulates Hepatocellular Carcinoma Tumorigenesis Through miR-486/CDK4 Pathway |
External Links
| Links for circ_0016788 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |