Basic Information
LncRNA/CircRNA Name | circ_0014130 |
Synonyms | |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | non small cell lung cancer |
ICD-0-3 | C34 |
Methods | qPCR, Microarray, other |
Sample | NSCLC tissues |
Expression Pattern | up-regulated |
Function Description | Only hsa_circ_0014130 exhibited significantly overexpressed in NSCLC tissues (P < 0.001), which were further confirmed in another 36 matched tissue samples using qRT-PCR. Hsa_circ_0014130 expression significantly correlated with TNM stage (P = 0.001) and lymphatic metastasis (P = 0.004). The area under the receiver operating characteristic curve was 0.878 (95% confidence interval = 0.804-0.951; P < 0.001), which showed good diagnostic potential. Bioinformatics platforms predicted that hsa_circ_0014130 might interact with five miRNAs and their corresponding mRNAs. Gene oncology analysis and pathway analysis revealed that hsa_circ_0014130 could participate in NSCLC development. |
Pubmed ID | 29440731 |
Year | 2018 |
Title | Microarray Profile of Circular RNAs Identifies hsa_circ_0014130 as a New Circular RNA Biomarker in Non-Small Cell Lung Cancer |
External Links
Links for circ_0014130 | GenBank HGNC NONCODE |
Links for non small cell lung cancer | OMIM COSMIC |