Basic Information
| LncRNA/CircRNA Name | circ_0012673 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, western blot, luciferase reporter assay, other |
| Sample | LAC tissues and cell lines (H1792, A549, PC9, H1703, H1793, H1299) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that the expression of hsa_circ_0012673 was up-regulated in LAC tissues compared to pair-matched adjacent non-tumor tissues (P = 0.0079), and that the expression level was associated with tumour size (P = 0.015). Furthermore, hsa_circ_0012673 was primarily localized in the cytoplasm and promoted cell proliferation of LAC cells by sponging miR-22, which targeted erb-b2 receptor tyrosine kinase 3 (ErbB3) in LAC. Hsa_circ_0012673 promotes LAC proliferation by suppressing miR-22, which targets ErbB3. |
| Pubmed ID | 29366790 |
| Year | 2018 |
| Title | Increased Circular RNA hsa_circ_0012673 Acts as a Sponge of miR-22 to Promote Lung Adenocarcinoma Proliferation |
External Links
| Links for circ_0012673 | GenBank HGNC NONCODE |
| Links for Lung Adenocarcinoma | OMIM COSMIC |