Basic Information
| LncRNA/CircRNA Name | circ_0007534 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, other |
| Sample | NSCLC tissues and cell lines (A549, H358, H1581,H1975 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | The results indicated that hsa_circ_0007534 was up-regulated in both NSCLC tissue samples and cell lines and this up-regulation is linked to lymph node invasion and advanced TNM stage. Hsa_circ_0007534 could also function as an unfavorable prognostic indicator for the patients with NSCLC. For the part of functional assays, down-regulation of hsa_circ_0007534 suppressed cell growth, migratory and invasive capacities; facilitating cell apoptosis in A549 and H1299 cells. Conversely, up-regulation of hsa_circ_0007534 caused the opposite biological behaviors. What's more, animal experiments validated the oncogenic role of hsa_circ_0007534.? |
| Pubmed ID | 30017736 |
| Year | 2018 |
| Title | Upregulation of Circular RNA hsa_circ_0007534 Predicts Unfavorable Prognosis for NSCLC and Exerts Oncogenic Properties in Vitro and in Vivo |
External Links
| Links for circ_0007534 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |