Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, RNAi, Western blot, Cell migration and invasion assay etc. |
| Sample | RB tissues, cell lines (SO-RB50, Y79 and WERI-RB1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of lncRNA CCAT1 in RB tissues was significantly increased compared with normal tissues. It was also shown that lncRNA CCAT1 in RB SORB50, Y79 and WERI-RB1 cells was significantly higher than that in normal podiatric retina. LncRNA CCAT1 promotes the proliferation migration and invasion, and reduces cell apoptosis of SO-RB50 and Y79 cells, probably through negative modulation of miR-218-5p. |
| Pubmed ID | 28088735 |
| Year | 2017 |
| Title | Long non-coding RNA CCAT1 promotes human retinoblastoma SO-RB50 and Y79 cells through negative regulation of miR-218-5p. |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |