Basic Information
| LncRNA/CircRNA Name | circSMARCA5 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, RNA-seq, RIP, other |
| Sample | HCC tissues |
| Expression Pattern | down-regulated |
| Function Description | The downregulation of cSMARCA5 in HCC was significantly correlated with aggressive characteristics and served as an independent risk factor for overall survival and recurrence-free survival in patients with HCC after hepatectomy. Our in vivo and in vitro data indicated that cSMARCA5 inhibits the proliferation and migration of HCC cells. Mechanistically, we found that cSMARCA5 could promote the expression of TIMP3, a well-known tumor suppressor, by sponging miR-17-3p and miR-181b-5p. |
| Pubmed ID | 29378234 |
| Year | 2018 |
| Title | Circular RNA cSMARCA5 Inhibits Growth and Metastasis in Hepatocellular Carcinoma |
External Links
| Links for circSMARCA5 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |