Basic Information
| LncRNA/CircRNA Name | circciRS-7 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, other |
| Sample | ESCC tissues and cell lines (KYSE150, KYSE140, KYSE70, Eca9706,EC18, and TE13) |
| Expression Pattern | up-regulated |
| Function Description | In vitro study showed that ciRS-7 can promote the migration and invasion of ESCC cells. Over expression of miR-7, one of well-known targets of ciRS-7, can attenuate ciRS-7 induced invasion of ESCC cells and over expression of matrix metalloproteinase 2 (MMP2). The expression of stem cell marker Kruppel-like factor-4 (KLF-4), which has been reported as the target of miR7, increased significantly in ciRS-7 transfected ESCC cells. Knockdown of KLF-4 also attenuated over expression of ciRS-7 induced cell invasion. In addition, BAY 11-7082, the inhibitor of NF-?B, partially reversed ciRS-7 induced cell invasion. Mechanically studies indicated that ciRS-7 increased the expression of p65 via increasing the phosphorylation of IKK-?. |
| Pubmed ID | 30207835 |
| Year | 2019 |
| Title | Circular RNA ciRS-7 Triggers the Migration and Invasion of Esophageal Squamous Cell Carcinoma via miR-7/KLF4 and NF-?B Signals |
External Links
| Links for circciRS-7 | GenBank HGNC NONCODE |
| Links for Esophageal squamous cell carcinoma | OMIM COSMIC |