Basic Information
| LncRNA/CircRNA Name | circZFR |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | thyroid cancer tissues and cell lines (K-1, TPC-1, SW579 and FTC133) |
| Expression Pattern | up-regulated |
| Function Description | Mechanistically, we found circZFR could promote C8orf4 expression via serving as a competing endogenous RNA (ceRNA) of miR-1261 in PTC cells. Rescue assays indicated that restoration of C8orf4 significantly attenuated the inhibitory effects of circZFR knockdown on PTC cell proliferation, migration and invasion. In summary, our findings demonstrated that circRNA circZFR exerted oncogenic roles via regulating miR-1261/C8orf4 axis in PTC, which suggested circZFR might be a potential therapeutic target. |
| Pubmed ID | 29842886 |
| Year | 2018 |
| Title | Circular RNA circZFR Contributes to Papillary Thyroid Cancer Cell Proliferation and Invasion by Sponging miR-1261 and Facilitating C8orf4 Expression |
External Links
| Links for circZFR | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |