Basic Information
| LncRNA/CircRNA Name | circ_0008717 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, RIP, other |
| Sample | osteosarcoma tissues and cell lines (MG-63, SAOS-2,U-2OS, HOS, SW1353) |
| Expression Pattern | up-regulated |
| Function Description | Gain and loss functional assays suggested that knockdown of circRNA-0008717 suppressed cell proliferation, migration and invasion, but promoted cell apoptosis. By using biotin-labeled circRNA-0008717 probe to perform RNA precipitation in osteosarcoma cells, we identified miR-203 as the circ0008717-associated microRNA. Subsequently, Bmi-1 was identified as the functional target of miR-203. In addition, overexpression of circRNA-0008717 in osteosarcoma could elevate Bmi-1 expression, resulting in the promotion of osteosarcoma cell proliferation and invasion. Furthermore, the tumor promoting effect of circRNA-0008717 was abolished by miR-203 mimics or Bmi-1 silencing vector. In conclusion, circRNA-0008717 plays an oncogenic role in osteosarcoma and may serve as a promising prognostic biomarker for osteosarcoma patients. |
| Pubmed ID | 29854278 |
| Year | 2017 |
| Title | Identification and Functional Characterization of circRNA-0008717 as an Oncogene in Osteosarcoma Through Sponging miR-203 |
External Links
| Links for circ_0008717 | GenBank HGNC NONCODE |
| Links for Osteosarcoma | OMIM COSMIC |