Basic Information
| LncRNA/CircRNA Name | circ_0084043 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, RNAi, other |
| Sample | malignant melanoma tissues andcell lines (SK-MEL-1, SK-MEL-5 and A875) |
| Expression Pattern | up-regulated |
| Function Description | High circRNA_0084043 expression was an independent risk factor of overall survival in melanoma patients. circRNA_0084043 promotes melanoma cell proliferation, invasion and migration. Bioinformatics and luciferase reporter assays confirmed that circRNA_0084043 directly binds to miR-153-3p, and Snail is directly targeted by miR-153-3p. We also demonstrated that circRNA_0084043 may act as the sponge of miR-153-3p to up-regulate Snail expression, and consequently function as an oncogene in melanoma. |
| Pubmed ID | 29777697 |
| Year | 2018 |
| Title | circRNA_0084043 Promote Malignant Melanoma Progression via miR-153-3p/Snail Axis |
External Links
| Links for circ_0084043 | GenBank HGNC NONCODE |
| Links for Melanoma | OMIM COSMIC |