Basic Information
| LncRNA/CircRNA Name | circPVT1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Doxorubicin and Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, other |
| Sample | osteosarcoma tissues and cell lines (SaoS2,KHOS, U2OS, MG63), serum |
| Expression Pattern | up-regulated |
| Function Description | CircPVT1 was significantly up-regulated in the OS tissues, serums and chemoresistant cell lines, correlated with poor prognosis of OS patients. Besides, ROC curve demonstrated that circPVT1 may be a better diagnostic biomarker than alkaline phosphatase (ALP) in OS with more sensitivity and specificity. In addition, functional assays revealed that circPVT1 knockdown by siRNA could weaken the resistance to doxorubicin and cisplatin of OS cells through decreasing the expression of classical drug resistance-related gene ABCB1. |
| Pubmed ID | 29559849 |
| Year | 2018 |
| Title | Overexpressed circPVT1, a Potential New Circular RNA Biomarker, Contributes to Doxorubicin and Cisplatin Resistance of Osteosarcoma Cells by Regulating ABCB1 |
External Links
| Links for circPVT1 | GenBank HGNC NONCODE |
| Links for Osteosarcoma | OMIM COSMIC |