Basic Information
| LncRNA/CircRNA Name | circPRKCI |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, western blot, luciferase reporter assay, RNAi, RIP, other |
| Sample | LAC tissues and cell lines (A549, NCI-H1975, NCI-H1703, NCI-H226, NCI-H46, PC9, NCI-H1299,7 SPC-A1, HCC827) |
| Expression Pattern | up-regulated |
| Function Description | circPRKCI was overexpressed in lung adenocarcinoma tissues, in part due to amplification of the 3q26.2 locus, and promoted proliferation and tumorigenesis of lung adenocarcinoma. circPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7 Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. In summary, circPRKCI is crucial for tumorigenesis and may serve as a potential therapeutic target in patients with lung adenocarcinoma. |
| Pubmed ID | 29588350 |
| Year | 2018 |
| Title | The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma |
External Links
| Links for circPRKCI | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |