Basic Information
| LncRNA/CircRNA Name | circNASP |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | osteosarcoma tissues and cell lines (143B and MG63) |
| Expression Pattern | up-regulated |
| Function Description | We found that circNASP knockdown dramatically inhibited the proliferation, cell cycle progression and invasion of OS cells. Moreover, we showed that circNASP expression was positively correlated with tumor size and metastasis in OS patients. In terms of mechanism, we found that circNASP acts as a sponge of miR-1253 targeting FOXF1 in OS cells. By inhibiting miR-1253 availability, circNASP promoted FOXF1 expression. Rescue assays indicated that inhibition of miR-1253 could significantly reverse the effects of circNASP knockdown on OS cell proliferation and invasion while restoration of FOXF1 rescued the proliferation and invasion of OS cells transfected with miR-1253 mimics. |
| Pubmed ID | 29678578 |
| Year | 2018 |
| Title | Circular RNA circNASP Modulates the Malignant Behaviors in Osteosarcoma via miR-1253/FOXF1 Pathway |
External Links
| Links for circNASP | GenBank HGNC NONCODE |
| Links for Osteosarcoma | OMIM COSMIC |