Basic Information
| LncRNA/CircRNA Name | circMYO9B |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, luciferase reporter assay, RNAi, other |
| Sample | Breast cancer tissues and cell lines (BT474, MCF-7, MDA-MB-231, T47D and MDA-MB-453) |
| Expression Pattern | up-regulated |
| Function Description | Moreover, we found that circMYO9B knockdown significantly suppressed the proliferation, migration and invasion of BC cells in vitro. In vivo assays also indicated that circMYO9B silence delayed tumor growth. In mechanism, we found that circMYO9B promoted the expression of FOXP4 by sponging miR-4316 in BC cells. We showed that the expression of miR-4316 was inversely associated with that of circMYO9B or FOXP4 in BC tissues. Finally, we found that restoration of FOXP4 expression significantly reversed the effects of circMYO9B knockdown on BC cell proliferation, migration and invasion. |
| Pubmed ID | 29702064 |
| Year | 2018 |
| Title | Circular RNA circMYO9B Facilitates Breast Cancer Cell Proliferation and Invasiveness via Upregulating FOXP4 Expression by Sponging miR-4316 |
External Links
| Links for circMYO9B | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |