Basic Information
| LncRNA/CircRNA Name | circHIPK3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Gallbladder Cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, western blot, other |
| Sample | gallbladder cancer tissues and cell lines (Mz-ChA-1, QBC939 and GBC-SD) |
| Expression Pattern | up-regulated |
| Function Description | circHIPK3 silencing by targeted siRNA potently inhibited survival and proliferation of established and primary human gallbladder cancer cells, while inducing cell apoptosis. Conversely, ectopic over-expression of circHIPK3 can further promote cancer cell proliferation. In gallbladder cancer cells, circHIPK3 sponged the tumor-suppressive microRNA-124 (miR-124) to sequester and inhibit its activity, thereby leading to increased expression of miR-124 targets, including ROCK1 (rho-associated protein kinase 1) and CDK6 (rho-associated protein kinase). Ectopic over-expression of miR-124 b y a lentiviral vector mimicked and abolished actions by circHIPK3 siRNA in gallbladder cancer cells. At last, we show that circHIPK3 is upregulated in human gallbladder cancer tissues, which is correlated with miR-124 downregulation and ROCK1-CDK6 upregulation. |
| Pubmed ID | 29928876 |
| Year | 2018 |
| Title | Circular RNA HIPK3 Promotes Gallbladder Cancer Cell Growth by Sponging microRNA-124 |
External Links
| Links for circHIPK3 | GenBank HGNC NONCODE |
| Links for Gallbladder Cancer | OMIM COSMIC |