Basic Information
| LncRNA/CircRNA Name | circHIPK3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Epithelial Ovarian Cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, other |
| Sample | ovarian cancer tissues and cell lines (A2780, HO8910, SKOV3 and CAOV3 cells) |
| Expression Pattern | up-regulated |
| Function Description | We found that circHIPK3 was higher expressed in EOC tissues and cells compared to adjacent normal tissue and ovarian epithelium cell line, respectively. Higher circHIPK3 expression associated with lymph node invasion, FIGO stage, and worse DFS and OS of patients. Moreover, multivariate Cox analysis showed that higher circHIPK3 was an independent predictor of DFS and OS in EOC patients. |
| Pubmed ID | 29949144 |
| Year | 2018 |
| Title | CircHIPK3 Is Upregulated and Predicts a Poor Prognosis in Epithelial Ovarian Cancer |
External Links
| Links for circHIPK3 | GenBank HGNC NONCODE |
| Links for Epithelial Ovarian Cancer | OMIM COSMIC |