Basic Information
| LncRNA/CircRNA Name | circFADS2 |
| Synonyms | circ_100833 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, luciferase reporter assay, Microarray, other |
| Sample | lung cancer tissues and cell lines (A549,H1299, SK-MES-1, and NCI-H1975) |
| Expression Pattern | up-regulated |
| Function Description | In vitro assays results showed that circFADS2 inhibition suppressed lung cancer cells proliferation and invasion ability. Bioinformatics analysis showed that miR-498 contained the complementary binding region of circFADS2, which was confirmed by Dual-luciferase reporter assay. In addition, the expression of miR-498 was down-regulated and negatively associated with circFADS2 expression in nonsmall cell lung cancer. Furthermore, rescue assays showed that miR-498 inhibitors abolished the effects of circFADS2 inhibition on lung cancer cells progression. Taken together, our findings indicated that circFADS2 was an effective tumor promoter in lung cancer progression, and its functions were performed by regulating the expression of miR-498. |
| Pubmed ID | 29700215 |
| Year | 2018 |
| Title | circFADS2 Regulates Lung Cancer Cells Proliferation and Invasion via Acting as a Sponge of miR-498 |
External Links
| Links for circFADS2 | GenBank HGNC NONCODE |
| Links for Lung Cancer | OMIM COSMIC |