Basic Information
| LncRNA/CircRNA Name | circC3P1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | HCC tissues and cell lines (BEL7402, Hep3B, HuH7 and MHCC97-L) |
| Expression Pattern | down-regulated |
| Function Description | And our results indicated that circC3P1 expression level was negatively correlated with TNM stage, tumor size and vascular invasion in HCC. Moreover, we found that circC3P1 overexpression dramatically inhibited the proliferation, migration and invasion of HCC cells in vitro and in vivo. In terms of mechanism, we found that circC3P1 could promote PCK1 expression through sponging miR-4641 in HCC cells. We showed that miR-4641 expression was negatively correlated with that of either circC3P1 or PCK1 in HCC tissues. Finally, by functional experiments, we demonstrated that knockdown of PCK1 significantly attenuated the effects of circC3P1 overexpression on HCC cell proliferation, migration and invasion. |
| Pubmed ID | 29608893 |
| Year | 2018 |
| Title | Circular RNA circC3P1 Suppresses Hepatocellular Carcinoma Growth and Metastasis Through miR-4641/PCK1 Pathway |
External Links
| Links for circC3P1 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |