Basic Information
| LncRNA/CircRNA Name | circBANP |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | lung cancer tissues and cell lines (H1299, A549, H23 and H522) |
| Expression Pattern | up-regulated |
| Function Description | Higher circ-BANP expression was associated with lower survival rate. Moreover, silencing circ-BANP markedly inhibited proliferation, migration and invasion of lung cancer cells in vitro and impaired tumor propagation in vivo. In mechanism, circ-BANP was identified as the sponge of miR-503 while miR-503 targets LARP1. Circ-BANP-induced inhibition of miR-503 led to increased expression of LARP1 in lung cancer. Finally, rescue assays indicated that LARP1 restoration partially reversed the effects of circ-BANP knockdown in lung cancer. |
| Pubmed ID | 29969631 |
| Year | 2018 |
| Title | CircRNA circ-BANP-mediated miR-503/LARP1 Signaling Contributes to Lung Cancer Progression |
External Links
| Links for circBANP | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |