Basic Information
| LncRNA/CircRNA Name | circ_0067934 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | HCC tissues and cell lines (BEL7402, Hep3B, HuH7 and MHCC97-L) |
| Expression Pattern | up-regulated |
| Function Description | Furthermore, we showed that circ_0067934 knockdown remarkably suppressed the proliferation, migration and invasion of Hep3B and HuH7 cells while inducing their apoptosis. In terms of mechanism, we found that circ_0067934 directly suppressed miR-1324, which targeted the 3'-UTR of FZD5 mRNA and subsequently downregulated the Wnt/?-catenin signaling pathway in HCC. Through rescue experiments, we demonstrated that circ_0067934 enhanced the proliferation, migration and invasion of HCC cells by the inhibition of miR-1324 and concomitant activation of FZD5/Wnt/?-catenin signaling pathway. |
| Pubmed ID | 29458020 |
| Year | 2018 |
| Title | CircRNA circ_0067934 Promotes Tumor Growth and Metastasis in Hepatocellular Carcinoma Through Regulation of miR-1324/FZD5/Wnt/?-catenin Axis |
External Links
| Links for circ_0067934 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |