Basic Information
| LncRNA/CircRNA Name | circ_001569 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, western blot, other |
| Sample | NSCLC tissues and cell lines (H460, H1299,SPC-A1 and A549) |
| Expression Pattern | up-regulated |
| Function Description | Increased circ_001569 expression was closely associated with tumor differentiation, lymph node metastasis and Tumor-Node-Metastasis classification in NSCLC. Patients that exhibited higher circ_001569 expression demonstrated a poorer survival outcome compared with patients with lower circ_001569 expression. Functional assay results indicated that the knockdown of circ_001569 inhibited the cell proliferation ability of NSCLC in vitro. In addition, it was identified that circ_001569 knockdown reduced the mRNA and protein expression levels of Wnt/?-catenin pathway-associated genes proto-oncogene protein Wnt1, transcription factor 4 and ?-catenin in NSCLC cells. |
| Pubmed ID | 29928432 |
| Year | 2018 |
| Title | Upregulation of circ_001569 Predicts Poor Prognosis and Promotes Cell Proliferation in Non-Small Cell Lung Cancer by Regulating the Wnt/?-catenin Pathway |
External Links
| Links for circ_001569 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |