Basic Information
| LncRNA/CircRNA Name | circCDR1as |
| Synonyms | circCDR1T, circciRS_7 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Bladder Cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, western blot, RIP, other |
| Sample | bladder cancer tissues and cell lines (EJ and T24) |
| Expression Pattern | down-regulated |
| Function Description | Cdr1as was significantly down-regulated in bladder cancer tissues compared with adjacent normal tissues. Overexpression of Cdr1as inhibited the proliferation, invasion and migration of bladder cancer cells in vitro and slowed down tumour growth in vivo. Cdr1as sponged multiple miRNAs in bladder cancer. Moreover, Cdr1as directly bound to miR-135a and inhibited its activity in bladder cancer. |
| Pubmed ID | 29694981 |
| Year | 2018 |
| Title | CircRNA-Cdr1as Exerts Anti-Oncogenic Functions in Bladder Cancer by Sponging MicroRNA-135a |
External Links
| Links for circCDR1as | GenBank HGNC NONCODE |
| Links for Bladder Cancer | OMIM COSMIC |