Basic Information
| LncRNA/CircRNA Name | circCDR1as |
| Synonyms | circCDR1T, circciRS_7 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Laryngeal Squamous Cell Carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, other |
| Sample | LSCC tissues and cell lines (Hep2 and AMC??N??) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of CDR1as in vitro enhanced cell vitality, and promoted the proliferation, migration, and invasion of two LSCC cell lines (Hep2 and AMC-HN-8.) However, these effects could be abrogated by knockdown of CDR1as or the forced expression of miR-7. Mechanistically, overexpressed CDR1 molecules functioned as miR-7 sponges and upregulated the key targets of miR-7, CCNE1, and PIK3CD in Hep2 and AMC-HN-8 cells. In vivo studies demonstrated the tumourigenic role of CDR1as. Overexpression of CDR1as alone promoted tumour growth and increased expression of the proliferation indices ki-67, CCNE1, and PIK3CD. Although the tumour suppressor miR-7 effectively inhibited the tumour growth, this effect could be counteracted by co-treatment with CDR1as in vivo. |
| Pubmed ID | 30182381 |
| Year | 2018 |
| Title | CDR1as Is Overexpressed in Laryngeal Squamous Cell Carcinoma to Promote the Tumour's Progression via miR-7 Signals |
External Links
| Links for circCDR1as | GenBank HGNC NONCODE |
| Links for Laryngeal Squamous Cell Carcinoma | OMIM COSMIC |