Basic Information
| LncRNA/CircRNA Name | circEPSTI1 |
| Synonyms | circ_000479 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, RNase R digestion, Actinomycin D assay, CCK8 assay, 5-Ethynyl-2??deoxyuridine (EdU) assay and apoptosis assay, Colony formation assay, Luciferase reporter assay, Western blot, Mouse xenograft model, In situ hybridization (ISH) and immunohistochemistry (IHC) analysis |
| Sample | TNBC tumor tissues, normal mammary epithelial cell lines (MCF-10A,184A1), breast cancer cell lines (HCC38, HCC1806, BT549, MDA-MB-231, MDA-MB-468, MDA-MB-415, MCF-7, T47D, BT474 and Skbr-3) and embryonic kidney 293T cells (HEK 293T cells) |
| Expression Pattern | up-regulated |
| Function Description | the expression profile of human circRNAs in TNBC tissues and identified circEPSTI1 (hsa_ circRNA_000479) as a significantly upregulated circRNA. Knockdown of circEPSTI1 inhibits TNBC cell proliferation and induces apoptosis. In vitro and in vivo experiments indicated that circEPSTI1 binds to miR-4753 and miR-6809 as a miRNA sponge to regulate BCL11A expression and affect TNBC proliferation and apoptosis. High levels of circEPSTI1 correlate with reduced survival in TNBC patients. |
| Pubmed ID | 30083277 |
| Year | 2018 |
| Title | circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression |
External Links
| Links for circEPSTI1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |