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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	papillary thyroid cancer
ICD-0-3	NA
Methods	qRT-PCR, MTT assay, Colony formation assay, Flow cytometry, Dual luciferase activity assay, Tumor formation in nude mice
Sample	PTC tissue, thyroid follicular epithelial cells (Nthy-ori 3-1) cells and PTC cells lines (BCPAP, TPC, K1, and IHH4)
Expression Pattern	up-regulated
Function Description	hsa_circ_0004458 was upregulated in PTC tissues and cells, while silencing of hsa_ circ_0004458 suppressed PTC cell proliferation and promoted PTC cell cycle arrest and apoptosis in vitro. Tumor formation assay in nude mice showed that knockdown of hsa_circ_0004458 by siRNAs inhibited the growth of PTC tumor in vivo. In addition, we found that miR-885-5p was a direct target of hsa_circ_0004458, and silencing of hsa_circ_0004458 inhibited PTC cell proliferation by miR-885-5p. We also demonstrated that RAC1 was a direct target of miR-885-5p and silencing of RAC1 suppressed PTC cell proliferation. Conclusions: We found that hsa_circ_0004458 promoted the progression of PTC by inhibition of miR-885-5p and activation of RAC1, and hsa_circ_0004458 may serve as a potential therapeutic target and biomarker for PTC.
Pubmed ID	30086127
Year	2018
Title	Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1

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