Basic Information
| LncRNA/CircRNA Name | circCFH |
| Synonyms | circ_0015758 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, CCK-8, Colony formation assays, Tumor xenograft growth assays, Ki-67 staining assays, Dual luciferase activity assay |
| Sample | glioma tumor tissues, Primary normal human astrocytes (NHAs), glioblastoma cell lines U87, A172, U251, TJ905, and U373 |
| Expression Pattern | up-regulated |
| Function Description | Circ-CFH expression was significantly upregulated in glioma tissue and was correlated with tumor grade.?CircCFH expression levels were also markedly higher in U251 and U373 glioma cell lines.?Circ-CFH knockdown inhibited cell proliferation and colony formation abilities.?Luciferase assays indicated that circ-CFH functions as a miR-149 sponge and inhibits its function in U251 and U373 cells.?Subsequently, AKT1 was identified as a direct target of the circ-CFH/miR-149 axis. |
| Pubmed ID | 30111766 |
| Year | 2018 |
| Title | Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR149 and Regulating AKT1 |
External Links
| Links for circCFH | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |