Basic Information
| LncRNA/CircRNA Name | circRBMS3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT??CR, CCK??, Flow cytometry cell cycle assay, Cell invasion assay, Dual luciferase reporter assay, In vivo tumorigenesis |
| Sample | GC tissues, GC cell lines (SGC??901, MKN??8, MKN??5, HGC??7, BGC??23, and AGS) and normal gastric epithelial cell line GES?? |
| Expression Pattern | up-regulated |
| Function Description | high throughput microarray assay showed that circRBMS3 was upregulated in GC tissues, which was further confirmed by quantitative reverse transcription polymerase chain reaction. Correlation analysis revealed that high circRBMS3 expression was associated with advanced TNM stage, depth of invasion, and lymph node metastasis. Kaplan Meier analysis indicated that GC patients with high circRBMS3 expression have a poor overall survival (OS). Function assays showed that circRBMS3 silencing reduced GC cells proliferation and invasion in vitro, and inhibited the tumor growth in vivo. Mechanistically, we found that miR 153 could act as a target of circRBMS3. Subsequently, we showed that circRBMS3 promoted snail family zinc finger 1 (SNAI1) expression via inhibiting miR 153 in GC cells. Collectively, these results suggested that circRBMS3 promoted GC cells proliferation and invasion via regulating miR 153/SNAI1 axis. |
| Pubmed ID | 30132886 |
| Year | 2018 |
| Title | CircRBMS3 promotes gastric cancer tumorigenesis by regulating miR??53??NAI1 axis |
External Links
| Links for circRBMS3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |